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Efficacy of micafungin against deep-seated candidiasis in cyclophosphamide-induced immunosuppressed mice.

Ninomiya M, Mikamo H, Tanaka K, Watanabe K, Tamaya T

Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, Gifu, Japan.

OBJECTIVES: We investigated the effects of fluconazole and micafungin for the therapy of deep-seated candidiasis in a cyclophosphamide-induced immunosuppressed mouse model. METHODS: We used the experimental model of intraperitoneal fungal abscess caused by Candida albicans, as described previously. RESULTS AND CONCLUSIONS: Micafungin efficacy was equal to that of fluconazole in one-tenth dosage even in peritonitis. We also assessed the short-term (24 h) and long-term (8 days) therapeutic effects after the end of therapy. Although the therapeutic effect of fluconazole was similar to that of micafungin at 24 h after the end of therapy, the effect of micafungin was superior to that of fluconazole at 8 days after the end of therapy.

Published 25 March 2005 in J Antimicrob Chemother, 55(4): 587-90.
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