Thrush Research Today is a free monthly online journal that collates and summarizes the latest research about Thrush, including details on oral, vaginal, symptoms, prevention, treatment, infection.

Breakthrough candida Infection in a preterm infant with congenital cutaneous Candida albicans infection.

Adler A, Litmanovitz I, Regev R, Arnon S, Bauer S, Dolfin T

Department of Neonatology, Meir Medical Center, Kfar-Saba 95847, Israel.

Amphotericin B is the primary antifungal agent used for candida sepsis in neonates. Breakthrough candidemia was not reported in neonates during either amphotericin B or liposomal amphotericin B (AmBisome) treatment. We describe a case of a premature infant with congenital cutaneous candida infection, who had two episodes of breakthrough infection, from Candida albicans and Candida parapsilosis, while he was treated with amphotericin B and AmBisome, respectively. We discuss the pathogenesis of breakthrough infections, and the relevance of antifungal resistance and sensitivities testing.

Published 19 April 2005 in Am J Perinatol, 22(3): 169-72.
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