Thrush Research Today is a free monthly online journal that collates and summarizes the latest research about Thrush, including details on oral, vaginal, symptoms, prevention, treatment, infection.

CpG oligodeoxynucleotides increase the susceptibility of normal mice to infection by Candida albicans.

Ito S, Pedras-Vasconcelos J, Klinman DM

Section of Retroviral Immunology, CBER/FDA, Bethesda, MD 20892, USA.

Synthetic oligodeoxynucleotides containing CpG motifs trigger an innate immune response that typically increases host resistance to infection. Yet CpG treatment reduces the resistance of normal mice to Candida albicans infection. This effect is mediated by CpG-induced interleukin-12, indicating that CpG-dependent cytokine production may have adverse consequences for the host.

Published 22 August 2005 in Infect Immun, 73(9): 6154-6.
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